Genetics and Hormones as Causes of Prostatitis

Genetics and Hormonal as Causes of Prostatitis

Genetics and hormones may play a role in the development of prostatitis. Genetics is your family history of passing down or inheriting genes from generation to generation. For example, it has been suggested that a family history of prostate disorders is associated with an increased risk of developing chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). However, little is understood about the potential role of genetic as a cause of chronic prostatitis, and further research is needed to determine if there is a connection.

Hormones, or more specifically, hormone imbalance, has been proposed as a cause of chronic prostatitis symptoms. The role of hormones in chronic prostatitis is controversial, however, and it is not well studied. A study on rats concluded that genetics, advancing age, and hormonal imbalance are all important factors in prostatitis.

An autoimmune process may be involved and experimental evidence indicates that this can be under hormonal influence. Recent findings include possible defects in the androgen receptor. The prostate may not even be the source of the symptoms. Pelvic pain also correlates with the neurotrophin nerve growth factor implicated in neurogenic inflammation and central sensitization. Finally, psychological stress may produce measurable biochemical changes and influence the other processes. The role of normal prostatic bacterial flora in inciting the inflammatory response has also been reconsidered.

Besides genetics and hormones, possible related chronic prostatitis causes include stress and emotional health, mast cells, inflammation, and neutrophil dysfunction. These are related to immune or hormone responses and disorders and can increase inflammation. Inflammation is one of the chronic prostatitis causes and can lead to other causes of pelvic pains such as pelvic floor disorder and chronic tension disorder.

There are several natural prostatitis treatments you can turn to if your chronic prostatitis may stem from genetics and hormones. Prostate supplements and diet can help support a healthy immune system and even help balance your hormones. Knowing what foods to avoid for prostatitis can help keep inflammation down. Alternative prostatitis treatments that may be helpful include stress management and related relaxation exercises such as meditation, yoga, and tai chi. Some patients also do well with biofeedback therapy.


Pontari MA et al. Mechanisms in prostatitis/chronic pelvic pain syndrome. Journal of Urology 2004 Sep; 172(3): 839-45