Quercetin for Prostatitis
What is Quercetin?
Quercetin for prostatitis is a supplement and natural treatment that has been gaining respect of the medical community. This flavonoid is found in many plants and foods, especially red grapes, red wine, apples, tea, berries, and onions. For over a decade, quercetin has been recognized as a potent antioxidant that has anti-inflammatory and anti-allergy effects by inhibiting the production and release of histamine and other inflammatory factors.
Quercetin for prostatitis is an option to relieve symptoms associated with prostate problems, and it has been identified as being beneficial in cases of chronic prostatitis in numerous studies, usually at a dose of 500 mg daily. When quercetin is combined with pollen extracts you may see it under the name of phytotherapy, which is part of Dr. Geo’s “NPAT” CPPS Treatment Program as well as the UPOINT system for prostatitis treatment.
Quercetin for Prostatitis—Does It Work?
Quercetin is a Tier 1 Supplement, meaning it has many successful clinical studies and research that support its effectiveness. Plus, quercetin is one of the recommended treatments though the UPOINT System for Prostatitis Treatment that is used by medical professionals looking to diagnose and treat prostatitis patients.
- There are several studies on using quercetin for chronic nonbacterial prostatitis. In one randomized, double-blind study that was published in Urology, 28 men who had chronic nonbacterial prostatitis/chronic pelvic pain syndrome (CP/CPPS) took either a placebo or 500 mg of quercetin twice a day for one month. The study’s authors also conducted a follow-up unblind, open-label study that involved an additional 17 men who received a supplement that contained quercetin, as well as other ingredients. At the end of the month, the men’s International Prostate Symptom Score (IPSS) fell from 21.0 to 13.1 in the quercetin group and from 20.2 to 18.8 in the placebo group. An improvement in symptoms of at least 25% was reported by 20% of patients taking placebo and 67% of patients taking quercetin. In the 17 patients who took the combined ingredients, 82% had at least a 25% improvement in their symptom score. Overall, the authors noted that quercetin “provides significant symptomatic improvement” in men who have CP/CPPS. (Shoskes 1999)
- The same author of the previous study also conducted a multimodal study involving quercetin over 10 years later. This study involved 100 men with CP/CPPS. Quercetin was associated with a greater decline in CPPS symptoms than other approaches.
- In 1999, researchers reported that quercetin “provides significant symptomatic improvement” in patients with CP/CPPS. Two-thirds of the men in the study reported that their quality of life had improved after receiving treatment with quercetin. The authors attributed the positive results to quercetin’s anti-inflammatory and antioxidant properties.
A more recent study conducted at Cleveland Clinic included 100 men who had CP/CPPS. The study used a multimodal therapy based on the UPOINT phenotype as follows:
– urinary: alpha blocker or antimuscarinic;
– organ-specific: quercetin;
– tenderness: physical therapy;
– psychosocial; infection; and
– neurologic/systemic). The men participated in the therapy for 26 weeks, and the main endpoint was a minimum 6-point decline in NIH-Chronic Prostatitis Symptom Index (CPSI).
A median of 3 UPOINT domains were positive: organ-specific (70%), tenderness (64%), and urinary (59%). At a median 50-week follow-up, 84% of the men had at least a 6-point decline in CPSI. The number of domains and initial CPSI were not predictors of a man’s response. Although no one domain predicted outcome, quercetin’s use was associated with a greater CPSI decrease. (Shoskes 2010)
Besides being helpful for Chronic Prostatitis/CPPS, studies indicate that quercetin may also help men with chronic bacterial prostatitis, especially when combined with other supplements.
- A prospective, randomized study was conducted to determine the therapeutic effect of combining extracts of quercetin and curcumin with saw palmetto and stinging nettle compared with the antibiotic prulifloxacin in men with chronic bacterial prostatitis. A total of 143 patients were split into two groups. Group A (106 patients) received both prulifloxacin (600 mg daily) plus the combined natural ingredients for 14 days. Group B (37 men) received the antibiotic only. After one month, 89.6% of men who received the natural formulas had no symptoms of prostatitis compared with only 27% of the men in the antibiotic-only group. Six months after the intervention portion of the study ended, no patients in Group A had recurrence of prostatitis compared with two patients in Group B. The authors concluded that the association of quercetin, curcumin, saw palmetto, and stinging nettle extracts can improve the clinical efficacy of prulifloxacin in men who have chronic bacterial prostatitis. (Cai 2009)
Because CP/CPPS can cause some urinary symptoms similar to a different prostate condition, enlarged prostate (benign prostatic hyperplasia—BPH), it can be helpful to look at studies on how quercetin works for that condition as well.
- In a study that was published in the Journal of Endocrinology, scientists reported on their evaluation of the effect of quercetin and the BPH drug Proscar (finasteride) on the prostate gland in rats. The quercetin (at doses of 50, 100, or 150 mg of quercetin per kg of body weight) along with the Proscar resulted in a 31.8%, 40.0%, and 48.2% reduction, respectively, in prostate weight. The authors concluded that quercetin works with finasteride to reduce prostate weight through a cell cycle-related pathway that may function independent of androgens.
Uses and Side Effects of Quercetin
Many of the studies on quercetin for prostatitis had participants taking 500 mg of quercetin per day. Do not exceed 1 gram daily of quercetin without consulting your healthcare provider. Side effects may include headache and stomach upset.
It is important to note that quercetin is contraindicated with certain antibiotics such called quinolones. Quercetin may decrease these drugs’ effectiveness. Commonly prescribed quinolones include Cipro, Levaquin, Floxin, and Avelox.
References for Quercetin for Prostatitis:
Cai T et al. Serenoa repens associated with Urtica dioica (ProstaMEV) and curcumin and quercitin (FlogMEV) extracts are able to improve the efficacy of prulifloxacin in bacterial prostatitis patients: results from a prospective randomized study. Int J Antimicrob Agents 2009 Jun; 33(6): 549-53
Kim YH, Lee YJ. TRAIL apoptosis is enhanced by quercetin through Akt dephosphorylation. J Cell Biochem 2007 Mar 1; 100(4): 998-1009
Lee DH et al. Role of Bax in quercetin-induced apoptosis in human prostate cancer cells. Biochem Pharmacol 2008 Jun 15; 75(12): 2345-55
Ma Z et al. Reduction of rat prostate weight by combined quercetin-finasteride treatment is associated with cell cycle deregulation. J Endocrinol 2004 Jun; 181(3): 493-507
Nair HK et al. Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diag Lab Immunol 2004 Jan; 11(1): 63-69
Senthilkumar K et al. Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Mol Cell Biochem 2010 Nov; 344(1-2): 173-84
Shoskes DA et al. Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial. Urology 1999; 54(6):960-63.
Shoskes DA et al. Phenotypically directed multimodal therapy for chronic prostatitis/chronic pelvic pain syndrome: a prospective study using UPOINT. Urology 2010 Jun; 75(6): 1249-53
University of Maryland Medical Center quercetin for prostatitis
Vijayababu MR et al. Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3). Mol Cell Biochem 2006 Jul; 287(1-2): 109-16 quercetin for prostatitis