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Anti-Depressives for Prostatitis

anti-depressives for prostatitis

What Are They?

Anti-depressives for prostatitis may be prescribed for men who suffer from chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). A doctor may recommend a tricyclic antidepressant to help with pain, urinary problems, or even some of the psychological depression that can occur from dealing with a frustrating ongoing medical condition like prostatitis. A doctor will usually prescribe anti-depressives for prostatitis after other treatments have not worked.

Anti-depressives can relieve prostatitis pain by treating something known as “neuropathic pain.” Neuropathic pain is pain caused by damage or disease that affects the sensory system in the body. The drug’s effects are produced by inhibiting serotonin and nonadrenaline re-uptake. This increases the concentration of serotonin in the central nervous system and helps relieve depression. These drugs also block sodium channels. Anti-depressives for prostatitis may include:

  • Elavil (amitriptyline)
  • Luvox (fluvoxamine)
  • Pamelor (nortriptyline)
  • Tofranil (imipramine)

Besides pain relief, anti-depressives for prostatitis have side effects that may have a beneficial effect on urinary frequency. In fact the drug imipramine may be prescribed for patients with urinary frequency and urgency. Other common anti-depressive drugs prescribed for prostatitis include amitripyline (Elavil) and nortriptyline. Nortriptyline may produce less drowsiness than amitriptyline, which is worth noting. These drugs can cause a dry mouth and sexual dysfunction. They can cause more severe side effects in older people. You should not suddenly stop taking antidepressant medication without first talking to your doctor. It is better to taper off this kind of medication to help manage side effects of going off the medications.

Another type of anti-depressive called Luvox has been shown to help men with pain and urinary flow. Luvox is in a class of antidepressants called SSRIs. This class also includes Paxil, Prozac, and Zoloft. In a study done by the drug’s manufacturer, 42 men ages 18 to 72 with CPPS took either a placebo or Luvox for eight weeks. The Luvox group had significant pain reduction after four weeks. In addition to prostate pain relief, 88% of the men in the Luvox group also experienced improved urinary flow while only 16% of the men in the placebo group reported improved urinary symptoms.

Anti-depressives for prosatitis are usually prescribed only after other traditional methods have not worked. If your doctor prescribes anti-depressives, you should continue to see your doctor regularly so that you can monitor the effects of the medication on your psychological and physical health. All of these anti-depressives contain a black box warning about the risk of suicidal thinking associated with these medications.

Chronic prostatitis usually does involve trying several different treatments before you can find relief. Consider looking into natural prostatitis treatments, such as supplements, and alternative prostatitis treatments that may help you find relief for your prostatitis symptoms. Overall, a total multi-modal approach to prostatitis that applies UPOINT and/or the NPAT/CPPS protocol developed by Dr. Espinosa has the best chance of restoring long-term health.